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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KCNK18 All Species: 17.58
Human Site: S222 Identified Species: 42.96
UniProt: Q7Z418 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z418 NP_862823.1 384 43671 S222 G T C P S R P S C S M E L F E
Chimpanzee Pan troglodytes XP_521614 383 43558 S222 G T C P S R P S C S M E L F E
Rhesus Macaque Macaca mulatta XP_001095493 383 43605 S221 G K C P S R P S C S M E L F E
Dog Lupus familis XP_544037 381 43021 G219 G R C P S A P G G N A D L F E
Cat Felis silvestris
Mouse Mus musculus Q6VV64 394 44385 S234 S K D P P S P S C N V E L F E
Rat Rattus norvegicus Q6Q1P3 405 45333 S245 S R E P A S P S C N V E L F E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513320 339 38516 H179 L P T S G R R H S L Q C Q N E
Chicken Gallus gallus XP_001234729 358 41274 Y194 V R K K P A Q Y R N A Q I F E
Frog Xenopus laevis Q63ZI0 374 42700 T196 A Y Y Y C F I T L T T I G F G
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001022681 372 42061 K200 I L W H K K R K A A K I R R A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.8 97.4 73.9 N.A. 64.9 65.1 N.A. 44.5 41.6 20.5 N.A. N.A. N.A. N.A. 27.8 N.A.
Protein Similarity: 100 97.9 98.4 82.8 N.A. 76.9 76.5 N.A. 58.5 55.7 36.9 N.A. N.A. N.A. N.A. 48.1 N.A.
P-Site Identity: 100 100 93.3 53.3 N.A. 53.3 53.3 N.A. 13.3 13.3 6.6 N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 93.3 66.6 N.A. 66.6 73.3 N.A. 13.3 33.3 20 N.A. N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 20 0 0 10 10 20 0 0 0 10 % A
% Cys: 0 0 40 0 10 0 0 0 50 0 0 10 0 0 0 % C
% Asp: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 0 50 0 0 80 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 80 0 % F
% Gly: 40 0 0 0 10 0 0 10 10 0 0 0 10 0 10 % G
% His: 0 0 0 10 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 10 0 0 0 0 20 10 0 0 % I
% Lys: 0 20 10 10 10 10 0 10 0 0 10 0 0 0 0 % K
% Leu: 10 10 0 0 0 0 0 0 10 10 0 0 60 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 30 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 40 0 0 0 10 0 % N
% Pro: 0 10 0 60 20 0 60 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 10 10 10 0 0 % Q
% Arg: 0 30 0 0 0 40 20 0 10 0 0 0 10 10 0 % R
% Ser: 20 0 0 10 40 20 0 50 10 30 0 0 0 0 0 % S
% Thr: 0 20 10 0 0 0 0 10 0 10 10 0 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 10 10 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _